منابع مشابه
Fatty Acid Desaturases, Polyunsaturated Fatty Acid Regulation, and Biotechnological Advances
Polyunsaturated fatty acids (PUFAs) are considered to be critical nutrients to regulate human health and development, and numerous fatty acid desaturases play key roles in synthesizing PUFAs. Given the lack of delta-12 and -15 desaturases and the low levels of conversion to PUFAs, humans must consume some omega-3 and omega-6 fatty acids in their diet. Many studies on fatty acid desaturases as w...
متن کاملDietary ω-3 polyunsaturated fatty acid intake and risk for amyotrophic lateral sclerosis.
IMPORTANCE Amyotrophic lateral sclerosis (ALS) is a severe progressive disease that cannot be prevented or cured. Diet-derived long-chain polyunsaturated fatty acids (PUFAs) are incorporated in brain lipids and modulate oxidative and inflammatory processes and could thus affect ALS risk and progression. OBJECTIVE To examine the association between ω-6 and ω-3 PUFA consumption and ALS risk. ...
متن کاملPolyunsaturated fatty acid-specific elongation enzymes.
We have isolated a novel gene (GLELO) from Mortierella alpina and its homologue (CEELO1) from Caenorhabditis elegans and demonstrate the involvement of their encoded proteins in the elongation of C(18) polyunsaturated fatty acids.
متن کاملSuppression of fatty acid synthase promoter by polyunsaturated fatty acids.
Dietary polyunsaturated fat is known to suppress expression of fatty acid synthase (FAS), a central enzyme in de novo lipogenesis. The sterol regulatory element-binding protein (SREBP) has recently been shown to be involved in this suppression. We previously reported that the first 2.1 kb of the FAS promoter are sufficient for transcriptional induction by a high carbohydrate diet as well as sup...
متن کاملω-3 Polyunsaturated Fatty Acids on the Prognosis of Multiple Sclerosis: The Effect of Eicosapentaenoic acid
Multiple sclerosis (MS) is a chronic neurological disease that is a major cause of disability in young adults in Europe and North America [1]. The clinical course of MS is unpredictable and varies individually, with some patients experiencing minimal impairment. The majority of patients have a form of MS referred to as relapsing-remitting MS (RRMS) characterized by periods of clinical stability...
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ژورنال
عنوان ژورنال: Journal of Lipid Nutrition
سال: 1997
ISSN: 1883-2237,1343-4594
DOI: 10.4010/jln.6.73